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The proceedings contain 109 papers. The topics discussed include: dose intensity of palbociclib and initial body weight dosage: implications on progression free survival in 220 patients with ER+/HER2-negative metastatic breast cancer;characteristics of Nirmatrelvir/Ritonavir (Paxlovid) recipients and clinical interventions by oncology pharmacists at a tertiary outpatient cancer center;safe handling of non-carcinogenic drugs in the Ghent University Hospital: development, implementation and communication of hospital-specific guidelines;case series: use of olaparib in uncommon locations in patients with impaired homologous recombination;real-world data evaluation of medicines used in special situations in oncohematology: a retrospective study from a comprehensive cancer institution;Dostarlimab in the treatment of recurrent endometrial cancer: real life experience;medication-related osteonecrosis of the jaws and CDK4/6 inhibitors in breast cancer;and efficacy and safety outcomes of generic imatinib in adults with chronic myeloid leukemia (CML) following the switch from branded imatinib.
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Conducting virtual audits, conducting effective virtual training, and enhancing communications with suppliers to ensure an uninterrupted supply chain are among the changes implemented to maintain operations, stay compliant, and continue manufacturing medically necessary products. The necessity for virtual audits was to allow companies and regulators to continue to evaluate the compliance stature of manufacturers while respecting stay-at-home and social distancing requirements that prevented in-person site audits. Some of these venues are free, and some require a registration fee. supply chain quality Enhanced communication with suppliers to ensure an uninterrupted supply chain has also become a priority during the pandemic.
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The guidance states, "These preventative measures can include steps to prepare personnel such as: * "Educating employees on topics such as, in the case of a pandemic, personal hygiene (hand washing and coughing and sneezing etiquette), social distancing, and appropriate use of sick leave * "Encouraging employees to get immunized as appropriate by providing information on local vaccination services or by offering on-site vaccination services, if reasonable * "Providing information for and encouraging employees to develop family emergency preparedness plans * "Reviewing CGMP [current good manufacturing practice] regulations regarding appropriate sanitation practices and restriction of ill or sick employees from production areas (see 21 CFR [Code of Federal Regulations] 211.28)" (2). Examples include: * "Production equipment routine maintenance * "Utility system performance checks and maintenance (e.g., air temperature, lighting, compressed air) * "Environmental monitoring of facilities such as cell culture, harvesting, and purification rooms during production * "Stability testing for certain drug products and components * "Periodic examinations of data and of reserve samples" (2). EMA, Guidance on the Format of the Risk Management Plan (RMP) in the EU-in Integrated Format, EMA/164014/2018 Rev.2.0.1 accompanying GVP Module V Rev.2 Human Medicines Evaluation (EMA, 31 October 2018).
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[...]the economic downturns, social polarization, public health emergencies, widespread humanitarian emergencies, forced displacement, climate crises, and even COVID-19 are major threats to mental health in the Eastern Mediterranean Region. The Comprehensive Mental Health Action Plan 2013-2030 (8), the Regional Framework to Scaleup Action on Mental Health in the Eastern Mediterranean Region (9), the World Mental Health Report (10), and the associated tools and resources published by WHO provide strategic directions for addressing stigma and discrimination. Recommendations Through outreach activities and advocacy at national and subnational levels, Member States are to strengthen multisectoral partnerships, including with people who experience mental health disorders and their support networks, to leverage scarce resources for mental health and integrate anti-stigma actions into mental health law, policies, and interventions.
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According to the WHO, this virus still exists in many parts of the globe in some form or the other. After the end of the Cold War in the early 90s, the global geopolitical and geo-economic divide, consequent to the ongoing Russo-Ukraine War, has never been so harshly polarised. [...]it is pertinent to note what President Xi had spoken recently in the National People's Congress stating that he will endeavour to "more quickly elevating the armed forces to world-class standards-and make it a great wall of steel." Importantly, for decades, India does carry some moral authority with itself with its foreign policy based on the Nehruvian concept of nonalignment now aptly called 'strategic autonomy' which has been long respected by the 'third world' now referred to as the 'global south'.
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The proceedings contain 92 papers. The topics discussed include: cellular and humoral immune responses after SARS-CoV-2 vaccination in pediatric kidney recipients;adult outcomes of childhood-onset idiopathic nephrotic syndrome: findings from a health insurance database;the genetic landscape and clinical spectrum of nephronophthisis and related ciliopathies;translational profiling of developing podocytes during glomerulogenesis;MAGED2 is required under hypoxia for cAMP signaling by inhibiting MDM2-dependent endocytosis of G-Alpha-S;high throughput investigation of the metabolic flux of intact cortical kidney tubules;peritoneal membrane junction and solute transporter expression and function in health, CKD and PD;and Function and interaction of coronavirus ion channel proteins.
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Which reads: Chart 1. Top 50 Distribution of Countries by GHSI, November 2019 (n=50). (Table Presented). Reads up: Chart 1. Top 50 Distribution of Countries by GHSI, November 2019 (n=50). (Table Presented).Copyright © 2023, Associacao Brasileira de Pos - Graduacao em Saude Coletiva. All rights reserved.
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Declaration of Competing Interest statements were not included in the published version of the following articles that appeared in previous issues of Forensic Imaging. The appropriate Declaration/Competing Interest statements, provided by the Authors, are included below. First X-ray and CT-scan of a Brazilian macumba-curse [Forensic Imaging, 21, June 2020, 200380] 10.1016/j.fri.2020.200380 Anthropomorphy of sweat in reliquary guardians (Fang, Gabon): a CT scan study [Forensic Imaging, 21, June 2020, 200381] 10.1016/j.fri.2020.200381 Investigation of image forgery based on multiscale retinex under illumination variations [Forensic Imaging, 22, September 2020, 200385] 10.1016/j.fri.2020.200385 Nankeen ink model for histological distribution of solutions used in post mortem CT-angiography [Forensic Imaging, 22, September 2020, 200387] 10.1016/j.fri.2020.200387 Development of a sex estimation method for skulls using machine learning on three-dimensional shapes of skulls and skull parts [Forensic Imaging, 22, September 2020, 200393] 10.1016/j.fri.2020.200393 "Mummies outside their closets". Paleoradiological investigation of Egyptian mummified remains [Forensic Imaging, 22, September 2020, 200397] 10.1016/j.fri.2020.200397 Frontal sinus index for sex estimation: Is it possible? [Forensic Imaging, 23, December 2020] 10.1016/j.fri.2020.200407 Morphological and dimensional assessment of the maxillary sinus for human identification and sexual dimorphism: A study using CBCT [Forensic Imaging, 23, December 2020] 10.1016/j.fri.2020.200409 Declaration of Competing Interest: None declared The value of MRI for assessing danger to life in non-fatal strangulation [Forensic Imaging, 22, September 2020, 200398] 10.1016/j.fri.2020.200398 S2666-2256(20)30047-6 Michael Thali serves as the Editor-in-Chief of this journal, Forensic Imaging. The standard review process was followed and an editor who is not on the author panel has handled the review process for this paper. The authors had no influence over the peer review process. The final decision is made by an editor who is not on the author panel. The authors have no other competing interests to declare. Implications for forensic death investigations from first Swiss post-mortem CT in a case of non-hospital treatment with COVID-19 [Forensic Imaging, 21, June 2020, 200378] 10.1016/j.fri.2020.200378 S2666-2256(20)30027-0 Michael Thali serves as the Editor-in-Chief of this journal, Forensic Imaging. The standard review process was followed and an editor who is not on the author panel has handled the review process for this paper. The authors had no influence over the peer review process. The final decision is made by an editor who is not on the author panel. The authors have no other competing interests to declare. Full virtual autopsy in a case of a suicidal transthoracic gunshot injury [Forensic Imaging, 21, June 2020, 200368] 10.1016/j.fri.2020.200368 S2666-2256(20)30017-8 Michael Thali serves as the Editor-in-Chief of this journal, Forensic Imaging. The standard review process was followed and an editor who is not on the author panel has handled the review process for this paper. The authors had no influence over the peer review process. The final decision is made by an editor who is not on the author panel. The authors have no other competing interests to declare.Copyright © 2023
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The proceedings contain 115 papers. The topics discussed include: clinical and genetic predictors of sickle cell nephropathy in Malawi;clinicohematological characteristics of iron deficiency anemia and hemoglobinopathies in Pakistan;an experience of non-hospital based laboratory;assessment of hematological parameters of petrol filling workers at petrol stations in Ethiopia: a comparative cross-sectional study;burden and risk factor to acute myocardial ischemia in children with sickle cell anemia;dyslipidemia in transfusion-dependent-thalassemia patients and its correlation with serum vitamin D level;impact of COVID-19 pandemic to pre-transfusion hemoglobin level and frequency of transfusion in transfusion-dependent thalassemia patients in Indonesia;retinopathy in Egyptian patients with sickle cell disease;and dietary pattern, socio-demographic characteristics and nutritional status of pregnant women attending Barau Dikko teaching hospital and the need to develop recommended dietary allowance and dietary reference intakes for sickle cell disease patients.
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Charles Ross & Son Company www.mixers.com CO2-based Cleaning Jets ACP Systems' quattroClean snow jet technology is a cleanroom-compatible cleaning process that is dry and uses liquid, climate-neutral carbon dioxide (C02). ACP Systems www.acp-systems.com Double-Isolated Vial-Filling Machine Steriline's VFCM100, a vial-filling and capping machine equipped with a double-wall isolator, is a solution designed to increase contract development and manufacturing organization production capacity for COVID-19 vaccines. The machine is capable of reaching a production capacity of 6000 pieces per hour and was specifically developed for injectable drugs.
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The proceedings contain 96 papers. The topics discussed include: practical pharmacotherapy for opioid use disorder in the age of fentanyl;can COVID-19 cause acute psychosis in pediatric patients? a case report;a survey of bullying experiences in a child and adolescent psychiatric clinic population;acute emergence of suicidal thoughts following Lemborexant initiation: an adverse reaction case report;assessing the unmet clinical need and opportunity for digital therapeutic intervention in schizophrenia: perspective from people with schizophrenia;rapid antidepressant effects and MADRS item improvements with AXS-05 (DEXTROMETHORPHAN-BUPROPION), an oral NMDA receptor antagonist in major depressive disorder: results from two randomized double-blind, controlled trials;targeting lncRNA NEAT1 impedes Alzheimers disease progression via MicroRNA-193a mediated CREB/BDNF and NRF2/NQO1 pathways;and impact of AXS-05 (DEXTROMETHORPHAN-BUPROPION), an Oral NMDA receptor antagonist, on Anhedonic symptoms in major depressive disorder.
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The proceedings contain 117 papers. The topics discussed include: informing local policy through an audit of the assessment, management and outcomes of intermediate and high-risk patients with pulmonary embolism;an initial exploration into the use of a novel virtual reality system to aid rehabilitation in intensive care;surprising chest radiograph- air in mediastinum;exploring tissue donation as part of end-of-life wishes- a duty of care following death on ICU?;the impact of deprivation on respiratory support unit outcomes in COVID-19 patients, and highlights from wave 2 data in Portsmouth;survey of attitudes towards end of life care as a tool in identifying areas for improvement;a quality improvement project regarding family communication within critical care;sleep promotion in a busy inner city high dependency unit;findings from a regional survey of critical care nursing staff focusing on retention and factors that influence wellbeing;and tracking functional recovery post critical illness.